產品屬性：
產品名稱 | (-)-Cryptopleurine |
規格 | 1mg、5mg |
貨號 | EY-01Y20950 |
Cas No.: 482-22-4
別名: N/A
化學名: N/A
分子式: C24H27NO3
分子量: 377.5
溶解度:
儲存條件: -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
(-)-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities.1 It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50 = 3 nM for all).2 (-)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50 = 8.7 nM).3 (-)-Cryptopleurine (500 μg/ml) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV).1 It also inhibits protein synthesis by yeast and mammalian ribosomes.4,51.Wang, Z., Feng, A., Cui, M., et al.First discovery and stucture-activity relationship study of phenanthroquinolizidines as novel antiviral agents against Tobacco Mosaic Virus (TMV)PLoS One7(12)e52933(2012)
2.Banwell, M.G., Bezos, A., Burns, C., et al.C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic propertiesBioorg. Med. Chem. Lett.16(1)181-185(2006)
3.Cai, X.F., Jin, X., Lee, D., et al.Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cellsJ. Nat. Prod.69(7)1095-1097(2006)
4.Battaner, E., and Vazquez, D.Inhibitors of protein synthesis by ribosomes of the 80-S typeBiochim. Biophys. Acta254(2)316-330(1971)
5.Pestka, S., Rosenfeld, H., Harris, R., et al.Studies on transfer ribonucleic acid-ribosome complexes. XXI. Effect of antibiotics on peptidyl-puromycin synthesis by mammalian polyribosomesJ. Biol. Chem.247(21)6895-6900(1972)
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