產品屬性：

Cas No.: 288-94-8

化學名: 2H-tetrazole

分子式: CH2N4

分子量: 70.1

溶解度:

儲存條件:
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition:Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

IC50: Not available.Tetrazole is the simplest compound belonging to tetrazoles family, a class of synthetic organic heterocyclic compound consists of a 5-member ring of four nitrogen and one carbon atom. Tetrazoles have commonly been believed to have similar properties to carboxylic acids, and therefore make themselves excellent bioisosteres. Moreover, several pharmaceutical agents, for instance, losartan and candesartan (Angiotensin II receptor blockers), are considered as tetrazoles. Tetrazoles are often adopted in medicinal chemistry as a substitute for carboxylic acids because they share very similar proton dissociation properties. [1]In vitro: The acidity constant of tetrazole was detected and reported as 4.9. Four of the six angiotension II receptor antagonists clinically effective for treating hypertension contained a tetrazole. MTT, dimethyl thiazolyl diphenyl tetrazolium bromide, was regarded as a well-known tetrazole applied to quantify the respiratory activity of live cells. Some tetrazoles could also be used in DNA assays. [2]In vivo: So far, no in vivo data has been reported.Clinical trial: So far, no clinical trial has been conducted.
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