產品屬性：
產品名稱 | BPH-652 |
規格 | 5 mg、10 mg |
貨號 | EY-01Y18067 |
Cas No.: 157124-84-0
別名: N/A
化學名: N/A
分子式: C16H16K3O7PS
分子量: 500.63
溶解度: H2O : 25 mg/mL (49.94 mM; Need ultrasonic)
儲存條件: 4°C, away from moisture
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1].BPH-652 treatment (0.5 mg twice per day (days -1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group[1].[1]. Liu CI, et al. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 7;319(5868):1391-4.
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