產(chǎn)品屬性：
產(chǎn)品名稱 | OSBPL7-IN-1 |
規(guī)格 | 5 mg、10 mg、25 mg、50 mg |
貨號 | EY-01Y18056 |
Cas No.: 1269826-44-9
別名: N/A
化學名: N/A
分子式: C20H19Cl2F3N2O3
分子量: 463.28
溶解度: N/A
儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].OSBPL7-IN-1 (compound G or Cpd G; 1-10 μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1].OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1].[1]. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662.
特別提醒公司產(chǎn)品僅供科研使用
