產(chǎn)品屬性：
產(chǎn)品名稱 | SBI-425 |
規(guī)格 | 1mg、5mg、10mg、25mg、50mg、100mg、200mg、500mg |
貨號(hào) | EY-01Y17900 |
Cas No.: 1451272-71-1
別名: N/A
化學(xué)名: N/A
分子式: C13H12ClN3O4S
分子量: 341.77
溶解度: DMSO: 86.67 mg/mL (253.59 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor[1]. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiovascular parameters and survival at a dose that does not cause a detectable change in bone[2].[1]. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34.
[2]. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36.
特別提醒公司產(chǎn)品僅供科研使用
