產(chǎn)品屬性：
產(chǎn)品名稱 | SB 242235 |
規(guī)格 | 10mM*1mL in DMSO、2mg、5mg、10mg、50mg、100mg |
貨號(hào) | EY-01Y17110 |
Cas No.: 193746-75-7
別名: N/A
化學(xué)名: N/A
分子式: C19H20FN5O
分子量: 353.39
溶解度: DMSO: ≥ 48 mg/mL (135.83 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC50 of 1.0 μM in primary human chondrocytes[1].IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)[1]SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC50 of 1.0 μM in human chondrocytes stimulated with IL-1β[1].SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate[1]. Western Blot Analysis[1] Cell Line:Human chondrocytesSB242235 (100 mg/kg; p.o.) abolishes MAP-KAPK-2 activity and HSP27 phosphorylation[2].SB242235 inhibits expression of the pro-inflammatory cytokines interleukin (IL)-6 and KC (murine IL-8) and COX-2[2].SB-242235 is demonstrated non-linear elimination kinetics that manifested as a decrease in clearance with increasing dose and apparent oral bioavailability > 100% at high oral doses in rat and monkey[3].
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