產品屬性：

Cas No.: 1240398-16-6

別名: N/A

化學名: N/A

分子式: C16H18D6O7

分子量: 334.4

溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: Not Stable,PBS (pH 7.2): 1 mg/ml

儲存條件: Store at -80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Tetranor prostaglandin E metabolite-d6 (tetranor-PGEM-d6) contains six deuterium atoms at the 13, 13, 14, 14, 15, and 15 positions. It is intended for use as an internal standard for the quantification of tetranor PGEM by GC- or LC-mass spectrometry. Tetranor PGEM-d6 is the major urinary metabolite of PGE1 and PGE2. It is used as a urinary marker of PGE2 biosynthesis, and to monitor metabolism after infusion or injection of PGE1 as a pharmaceutical.1,2 Normal healthy males excrete 16-30 μg of tetranor PGEM over a 24-hour period. Females excrete less by about a factor of three. Following oral administration (4 x 50 mg/24 hours) of the COX inhibitor, indomethacin, urinary levels of tetranor PGEM decrease by 75-98% indicating the almost complete loss of PGE2 biosynthesis.11.Hamberg, M.Inhibition of prostaglandin synthesis in manBiochemical and Biophysical Research Communications49720-726(1972)

2.Honda, H., Fukawa, K., and Sawabe, T.Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E ratsProstaglandins19259-269(1980)
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