產品屬性：
產品名稱 | TFB-TBOA (hydrate) |
規(guī)格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y14439 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C19H17F3N2O6.XH2O
分子量: 426.3
溶解度: DMSO: 30 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC50 values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells.1 It is selective for EAAT1 and EAAT2 over EAAT3 (IC50 = 300 nM), as well as the choline, dopamine, GABA, norepinephrine, and serotonin transporters and a variety of neurotransmitter receptors at 10 μM. TFB-TBOA (10 μM) inhibits L-glutamate- and L-aspartate-induced currents in X. laevis oocytes. It induces convulsions in mice when administered at a dose of 0.2 μg/animal.1.Shimamoto, K., Sakai, R., Takaoka, K., et al.Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transportersMol. Pharmacol.65(4)1008-1015(2004)
特別提醒公司產品僅供科研使用
