產品屬性：
產品名稱 | STAD 2 |
規(guī)格 | 500 ug |
貨號 | EY-01Y12728 |
Cas No.: 1542100-77-5
別名: N/A
化學名: N/A
分子式: C102H182N24O22
分子量: 2096.68
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.Bendzunas et al (2018) Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 26 1174 PMID:29449124 |Flaherty et al (2015) The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 10 e0129239 PMID:26010880 |Wang et al (2014) Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 9 635 PMID:24422448
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