產品屬性：
產品名稱 | coumarin-SAHA |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y12679 |
Cas No.: 1260635-77-5
別名: coumarin-Suberoylanilide Hydroxamic Acid
化學名: N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide
分子式: C18H22N2O5
分子量: 346.4
溶解度: 5mg/mL in DMSO, 5mg/mL in DMF
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8. [2] This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.
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