產(chǎn)品屬性：
產(chǎn)品名稱 | WHI-P258 |
規(guī)格 | 10mM*1mL in DMSO、2mg、5mg、10mg、25mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y12705 |
Cas No.: 21561-09-1
別名: N/A
化學(xué)名: N/A
分子式: C16H15N3O2
分子量: 281.31
溶解度: DMSO: 31.25 mg/mL (111.09 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 μM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.
[2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.
特別提醒公司產(chǎn)品僅供科研使用
